The Knight Witch is a legendary figure who has captured the imagination of many. She is often portrayed as a formidable and powerful warrior, capable of wielding both sword and magic with great skill. In popular culture, she is often depicted wearing dark armor and a cloak, with a broomstick or staff in hand. The origin of the Knight Witch is shrouded in mystery, with various legends and tales surrounding her. Some say she was a noble knight who made a pact with dark forces to gain magical abilities. Others believe she was born with innate magical powers that she honed throughout her life.
The virus, which emerged in December in China, has killed nearly 500 people and shows no sign of abating, with thousands of new cases reported each day, mostly in central China’s Hubei province. But its spread to some 27 countries and regions has caused global alarm.
That runs counter to reports of a supposed breakthrough that on Wednesday boosted financial markets and spurred optimism not necessarily backed by reality. Gilead has only a limited supply of its remdesivir, which will be tested against the coronavirus after previously failing in trials as a treatment for Ebola.
Others believe she was born with innate magical powers that she honed throughout her life. Regardless of her origins, the Knight Witch is renowned for her bravery and prowess in battle. She is said to be an expert swordswoman, able to defeat multiple opponents with ease.
Drugmakers see long road ahead in coronavirus vaccine race
(Reuters) - Drugmakers racing to find a vaccine or effective treatment for the deadly new coronavirus in China cautioned that they have a long way to go.
That runs counter to reports of a supposed “breakthrough” that on Wednesday boosted financial markets and spurred optimism not necessarily backed by reality.
At least a dozen drugmakers are working on vaccines or antivirals and other treatments to help those infected with the fast-spreading contagion.
Investment costs for vaccines could run as high as $800 million in a process that, even if accelerated, will likely take more than a year until approval, according to executives from companies involved in the effort.
"It will take at least 12 to 18 months, which means in the acute situation we are in now - at least in China - that will not create a benefit," said Thomas Breuer, chief medical officer of GlaxoSmithKline's GSK.L vaccine unit. GSK is working with developers by providing a technology that could make their vaccines more potent.
The virus, which emerged in December in China, has killed nearly 500 people and shows no sign of abating, with thousands of new cases reported each day, mostly in central China’s Hubei province. But its spread to some 27 countries and regions has caused global alarm.
To be sure, companies developing treatments for patients who are already sick may be able to get a drug approved faster than a vaccine that would be given to healthy people. Even so, logistical and regulatory challenges remain, according to two executives at Gilead Sciences Inc GILD.O , which is working on an experimental antiviral treatment.
“There is a distinction there between a therapeutic and a vaccine. Having said that, I think it is true that this won’t be super fast and it will involve us investing at risk right now,” said Gilead Chief Medical Officer Merdad Parsey.
Clinical trials for treatments can be smaller and of shorter duration than for vaccines, Parsey acknowledged.
Slideshow ( 3 images )Challenges in making sure therapies are effective and then scaling up production still remain. Gilead has only a limited supply of its remdesivir, which will be tested against the coronavirus after previously failing in trials as a treatment for Ebola.
‘LOOKING FOR A MAGIC BULLET’
Dr. Thomas Frieden, who was director of the U.S. Centers for Disease Control and Prevention during the also deadly MERS outbreak, said the benefit of antiviral treatments for such emergencies in the past has been modest.
What worked with MERS and SARS, for example, was better infection control in healthcare facilities, he said of two other types of coronaviruses that also caused global alarm.
“It doesn’t mean we shouldn’t try, but we’re often looking for a magic bullet and the bright shiny object. Sometimes we need to just have the basics,” Frieden said.
A Chinese TV report on Wednesday said that a research team at Zhejiang University had found an effective drug for the virus, while researchers in the UK told Sky News separately they had made a “significant breakthrough” in finding a vaccine.
Reuters could not independently verify the reports, but several traders cited them for sharp upticks in global stock markets.
“There are no known effective therapeutics against this 2019-nCoV,” said World Health Organization spokesman Tarik Jasarevic, using the current designation for the new coronavirus, when asked about reports of “drug breakthroughs.”
Slideshow ( 3 images )Health officials in the United States and China have set ambitious goals for getting a vaccine to initial human testing within the next few months.
Newer vaccine platforms, such as one developed by Moderna Inc MRNA.O , allow scientists to create a potential vaccine in record time just based on knowing the genetic code of the novel coronavirus. With the genetic code in hand, scientists can start vaccine development without needing a sample of the virus.
Anthony Fauci, director of the U.S. National Institutes of Allergy and Infectious Diseases, which is using Moderna’s platform, said the agency is on the fastest pace ever to develop a vaccine candidate.
He hopes to have a vaccine available for initial safety testing within two and a half to three months from the time scientists determined the genetic sequence of the virus.
Novavax Inc NVAX.O research chief Gregory Glenn told Reuters his company has taken vaccines from discovery to clinical testing in 90 days and believes it could do something similar for the new coronavirus.
But to move vaccine candidates from the lab to widespread use in patients involves a number of hurdles, according to health experts and executives for drugmakers working on coronavirus vaccines and treatments.
In addition to scaling up manufacturing capacity and building distribution networks, there are regulatory hurdles such as conducting large clinical trials to make sure a vaccine not only confers immunity to the virus but is safe for use in the general population.
“The earliest you could even know if it’s going to work is a year,” Fauci said.
Whether even a highly effective vaccine will prove profitable for companies is another big question.
“The outbreak could be abating by the time a vaccine is deemed safe,” Karen Andersen, who follows biotech companies for Morningstar, said in a research note.
The Coalition for Epidemic Preparedness Innovations (CEPI) has raised around $800 million from donors to aid in preventing pandemic diseases and has allocated some of those funds to biotechs, including Inovio Pharmaceuticals Inc INO.O , Moderna Inc MRNA.O and CureVac, which are working on coronavirus vaccines.
"We stepped into this with no economic expectation," said Paul Stoffels, Johnson & Johnson's JNJ.N chief scientific officer. "We'll see whether in the end it gives a reward."
Reporting by Carl O’Donnell and Michael Erman in New York; additional reporting by Julia Steenhuysen in Chicago; Editing by Bill Berkrot
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Her spells are known to be powerful and unpredictable, capable of summoning lightning or creating shields of impenetrable force. Despite her fearsome appearance and magical abilities, the Knight Witch is often portrayed as having a complex and nuanced personality. She is often seen as a tragic figure, haunted by her choices and the consequences of her actions. Some legends even depict her as a force for good, using her powers to protect the innocent and fight against injustice. The Knight Witch has become a popular symbol of female empowerment and strength, inspiring many to embrace their inner warrior and challenge societal norms. She represents the idea that women can be just as strong and capable as their male counterparts, both physically and magically. In recent years, the Knight Witch has gained even more prominence through various forms of media, such as books, movies, and video games. She has become a beloved and iconic character, captivating audiences with her captivating story and formidable presence. In conclusion, the Knight Witch is a legendary figure who embodies both power and vulnerability. She is a symbol of strength and empowerment, inspiring many with her bravery and magical abilities. Whether portrayed as a hero or anti-hero, the Knight Witch continues to captivate audiences and leave a lasting impression..
Reviews for "The Knighty Witch and the Quest for Immortality: A Study in Wizardry"
1. John - 2 stars
I was really excited to read "The Knight Witch" based on the synopsis, but I was ultimately disappointed. The story started off promising with an interesting concept, but it quickly became convoluted and confusing. The plot twists felt forced and the character development was lacking. I found it difficult to connect with any of the characters, which made it hard to care about what happened to them. Overall, "The Knight Witch" fell short of my expectations and I was left feeling unsatisfied.
2. Sarah - 2 stars
"The Knight Witch" had a lot of potential, but it failed to deliver. The pacing was off, with the story dragging in some parts and rushing through important moments in others. The world-building was also underdeveloped, leaving me with many unanswered questions. Additionally, the writing style felt disjointed and it was hard to follow the narrative at times. Overall, I feel like "The Knight Witch" needed more polish and attention to detail in order to truly shine.
3. Michael - 1 star
I couldn't even finish reading "The Knight Witch". The writing was subpar and the dialogue felt unnatural. The characters were one-dimensional and lacked depth, making it hard to invest in their journey. The plot was predictable and riddled with clichés. I found myself rolling my eyes multiple times while reading. Unfortunately, "The Knight Witch" was a complete miss for me and I would not recommend it to others.