Magician pose reference A magician pose refers to a specific posture or position that magicians often adopt during their performances. It is a pose that exudes confidence, charisma, and a sense of mystery. Magicians use this pose to captivate their audience and create an air of intrigue around their tricks and illusions. The magician pose typically involves standing with one hand extended outward, palm facing upward, and the other hand slightly raised, holding a prop or accessory. The magician may also tilt their head slightly to the side, maintaining eye contact with their audience, and wearing a slight smile that suggests they are in control of the situation. This pose is often accompanied by specific body language and gestures.
The characters are a sheer delight, you feel a sense of belonging and knowing as soon as you meet them from the lovely but bold Cassie, the kind and dainty Tabitha, the heart of gold if a little rough around the edges Rue and the anxiety-ridden and rude perfectionist Ivy (Gilmore Girls fans will recognise Paris in her!!) who just wants to be the best- but maybe not for the reason you think.
LZR reports personal compensation for advisory board activities from Biogen, Genentech, and Novartis; and research support from Biogen, Celgene, and Genentech. ArrangeMe allows for the publication of unique arrangements of both popular titles and original compositions from a wide variety of voices and backgrounds.
This pose is often accompanied by specific body language and gestures. Magicians may use fluid hand movements or sleight of hand techniques to enhance the illusion they are creating. They may also incorporate other props or elements into their pose, such as a cape or hat, to further enhance the theatricality and showmanship of their performance.
Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial
Background: Treatment with natalizumab once every 4 weeks is approved for patients with relapsing-remitting multiple sclerosis, but is associated with a risk of progressive multifocal leukoencephalopathy. Switching to extended-interval dosing is associated with lower progressive multifocal leukoencephalopathy risk, but the efficacy of this approach is unclear. We aimed to assess the safety and efficacy of natalizumab once every 6 weeks compared with once every 4 weeks in patients with relapsing-remitting multiple sclerosis.
Methods: We did a randomised, controlled, open-label, phase 3b trial (NOVA) at 89 multiple sclerosis centres across 11 countries in the Americas, Europe, and Western Pacific. Included participants were aged 18-60 years with relapsing-remitting multiple sclerosis and had been treated with intravenous natalizumab 300 mg once every 4 weeks with no relapses for at least 12 months before randomisation, with no missed doses in the previous 3 months. Participants were randomly assigned (1:1), using a randomisation sequence generated by the study funder and contract personnel with interactive response technology, to switch to natalizumab once every 6 weeks or continue with once every 4 weeks. The centralised MRI reader, independent neurology evaluation committee, site examining neurologists, site backup examining neurologists, and site examining technicians were masked to study group assignments. The primary endpoint was the number of new or newly enlarging T2 hyperintense lesions at week 72, assessed in all participants who received at least one dose of assigned treatment and had at least one postbaseline MRI, relapse, or neurological examination or efficacy assessment. Missing primary endpoint data were handled under prespecified primary and secondary estimands: the primary estimand included all data, regardless of whether participants remained on the assigned treatment; the secondary estimand classed all data obtained after treatment discontinuation or study withdrawal as missing. Safety was assessed in all participants who received at least one dose of study treatment. Study enrolment is closed and an open-label extension study is ongoing. This study is registered with EudraCT, 2018-002145-11, and ClinicalTrials.gov, NCT03689972.
Findings: Between Dec 26, 2018, and Aug 30, 2019, 605 patients were assessed for eligibility and 499 were enrolled and assigned to receive natalizumab once every 6 weeks (n=251) or once every 4 weeks (n=248). After prespecified adjustments for missing data, mean numbers of new or newly enlarging T2 hyperintense lesions at week 72 were 0·20 (95% CI 0·07-0·63) in the once every 6 weeks group and 0·05 (0·01-0·22) in the once every 4 weeks group (mean lesion ratio 4·24 [95% CI 0·86-20·85]; p=0·076) under the primary estimand, and 0·31 (95% CI 0·12-0·82) and 0·06 (0·01-0·31; mean lesion ratio 4·93 [95% CI 1·05-23·20]; p=0·044) under the secondary estimand. Two participants in the once every 6 weeks group with extreme new or newly enlarging T2 hyperintense lesion numbers (≥25) contributed most of the excess lesions. Adverse events occurred in 194 (78%) of 250 participants in the once every 6 weeks group and 190 (77%) of 247 in the once every 4 weeks group, and serious adverse events occurred in 17 (7%) and 17 (7%), respectively. No deaths were reported. There was one case of asymptomatic progressive multifocal leukoencephalopathy (without clinical signs) in the once every 6 weeks group, and no cases in the once every 4 weeks group; 6 months after diagnosis, the participant was without increased disability and remained classified as asymptomatic.
Interpretation: We found a numerical difference in the mean number of new or newly enlarging T2 hyperintense lesions at week 72 between the once every 6 weeks and once every 4 weeks groups, which reached significance under the secondary estimand, but interpretation of statistical differences (or absence thereof) is limited because disease activity in the once every 4 weeks group was lower than expected. The safety profiles of natalizumab once every 6 weeks and once every 4 weeks were similar. Although this trial was not powered to assess differences in risk of progressive multifocal leukoencephalopathy, the occurrence of the (asymptomatic) case underscores the importance of monitoring and risk factor consideration in all patients receiving natalizumab.
Funding: Biogen.
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The magician pose serves multiple purposes. Firstly, it helps to establish the magician as the focal point of attention, drawing the audience's gaze towards them. By adopting a confident and commanding posture, the magician asserts their authority and control over the performance space. Secondly, the magician pose creates a sense of anticipation and suspense. The extended hand and raised accessory suggest that something magical is about to happen. This posture heightens the audience's curiosity and eagerness to see what the magician will do next. Lastly, the magician pose contributes to the overall image and persona of the magician. It is a visual representation of their craft and artistry. The pose reinforces the idea that the magician possesses special powers or abilities beyond those of ordinary individuals. In conclusion, the magician pose is a key element of a magician's performance. It conveys confidence, charisma, and mystery, capturing the audience's attention and setting the stage for an enchanting and captivating experience..
Reviews for "Unlock Your Hidden Abilities with the Magician Pose Reference"
1. Sarah - 2/5 - I was disappointed with the "Magician pose reference" because it lacked variety and creativity. The poses were very basic and generic, and I was hoping for more dynamic and interesting options. Additionally, the reference felt quite outdated, with poses that seemed more suited for a magician from the 90s rather than a modern performer. Overall, I found the reference to be uninspiring and not worth the money.
2. Mark - 3/5 - While the "Magician pose reference" provided some basic poses that could be useful for beginners, I felt that it fell short in terms of versatility and comprehensiveness. The poses seemed quite limited and repetitive, which made it difficult to find the right pose for specific magical tricks or performances. I was expecting a more comprehensive guide with a wider range of poses and variations. Although it had some value for novices, I would not recommend it for those looking to expand their magician's repertoire.
3. Emily - 2/5 - As an experienced magician, I found the "Magician pose reference" to be quite underwhelming. The poses provided were too basic and lacked the complexity necessary to create a captivating performance. They didn't offer any new or unique ideas that I hadn't already encountered in my years of practicing magic. I believe this reference would be more suitable for beginners or hobbyists looking for a starting point, but for serious magicians, it falls short in terms of providing fresh inspiration and innovative poses.