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Popular drug use reflects the times we live in, and the ways we want to escape them. Cocaine was the perfect partner to ride the frazzled, money-obsessed bullet train of the ’80s, while ecstasy’s blissed-out boom in the ’90s reflected the spirit pulsing through Cool Britannia. In the decades since, recreational drug trends have splintered, with the rise of sleeping pills such as Xanax and Valium, and huge demand for medical substances such as ketamine and GHB for recreational use. One common thread between these newer party drugs is the promise – however twisted or problematic – to slip away from the world or dissociate from it. The new shroom renaissance – post-pandemic, mid-climate crisis – speaks to a spiritually malnourished generation in need of a bump of euphoria.
The rise of mushrooms as a party drug has coincided with the publication of a raft of new research showing psilocybin s remarkable promise in treating mental health issues, including depression, OCD and anxiety. Psilocybin may be giving these individuals the temporary kick start they need to break out of their depressive states and these imaging results do tentatively support a reset analogy.
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Magic mushrooms 'reboot' brain in depressed people – study
Magic mushrooms may effectively “reset” the activity of key brain circuits known to play a role in depression, the latest study to highlight the therapeutic benefits of psychedelics suggests.
Psychedelics have shown promising results in the treatment of depression and addictions in a number of clinical trials over the last decade. Imperial College London researchers used psilocybin – the psychoactive compound that occurs naturally in magic mushrooms – to treat a small number of patients with depression, monitoring their brain function, before and after.
Images of patients’ brains revealed changes in brain activity that were associated with marked and lasting reductions in depressive symptoms and participants in the trial reported benefits lasting up to five weeks after treatment.
Dr Robin Carhart-Harris, head of psychedelic research at Imperial, who led the study, said: “We have shown for the first time clear changes in brain activity in depressed people treated with psilocybin after failing to respond to conventional treatments.
“Several of our patients described feeling ‘reset’ after the treatment and often used computer analogies. For example, one said he felt like his brain had been ‘defragged’ like a computer hard drive, and another said he felt ‘rebooted’.
“Psilocybin may be giving these individuals the temporary ‘kick start’ they need to break out of their depressive states and these imaging results do tentatively support a ‘reset’ analogy. Similar brain effects to these have been seen with electroconvulsive therapy.”
For the study, published in Scientific Reports on Friday, 20 patients with treatment-resistant depression were given two doses of psilocybin (10 mg and 25 mg), with the second dose a week after the first. Of these, 19 underwent initial brain imaging and then a second scan one day after the high dose treatment. The team used two main brain imaging methods to measure changes in blood flow and the crosstalk between brain regions, with patients reporting their depressive symptoms through completing clinical questionnaires.
Immediately following treatment with psilocybin, patients reported a decrease in depressive symptoms, such as improvements in mood and stress relief.
MRI imaging revealed reduced blood flow in areas of the brain, including the amygdala, a small, almond-shaped region of the brain known to be involved in processing emotional responses, stress and fear.
The authors believe the findings provide a new window into what happens in the brains of people after they have ‘come down’ from a psychedelic, with an initial disintegration of brain networks during the drug ‘trip’ followed by a re-integration afterwards.
The Imperial College researchers acknowledge that the significance of their results is limited by the small sample size and the absence of a control/placebo group for comparison. They also stress that it would be dangerous for patients with depression to attempt to self-medicate.
Professor David Nutt, director of the neuropsychopharmacology unit in the division of brain sciences, and senior author of the paper, said: “Larger studies are needed to see if this positive effect can be reproduced in more patients. But these initial findings are exciting and provide another treatment avenue to explore.”
The authors currently plan to test psilocybin against a leading antidepressant in a trial set to start early next year.
The research was supported by the Medical Research Council, the Alex Mosley Charitable Trust and the Safra Foundation.
My friend Lucia* first took magic mushrooms several years ago, in upstate New York. “The house that we were staying in overlooked this little forest, and as the moon was going down, the whole forest lit up with lightning bugs [fireflies],” she tells me. “On mushrooms it looked like the whole thing was made of glitter and I remember it absolutely blowing my mind.”
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