The Curse of the Black Pearl, the first installment of the Pirates of the Caribbean film series, was released in theaters on July 9, 2003. Directed by Gore Verbinski and produced by Jerry Bruckheimer, the film was based on the popular Disneyland attraction of the same name. Starring Johnny Depp as the iconic Captain Jack Sparrow, the Curse of the Black Pearl follows the story of a young blacksmith named Will Turner, played by Orlando Bloom, who teams up with Sparrow to rescue his love interest, Elizabeth Swann, portrayed by Keira Knightley. Their journey takes them on a thrilling adventure as they encounter cursed pirates led by Captain Hector Barbossa, played by Geoffrey Rush. The film received widespread critical acclaim for its captivating story, impressive visual effects, and memorable performances. Johnny Depp's portrayal of Captain Jack Sparrow, in particular, was highly praised for its unique and eccentric charm.

How to Make Magic Mouthwash

This article was co-authored by wikiHow staff writer, Megaera Lorenz, PhD. Megaera Lorenz is an Egyptologist and Writer with over 20 years of experience in public education. In 2017, she graduated with her PhD in Egyptology from The University of Chicago, where she served for several years as a content advisor and program facilitator for the Oriental Institute Museum’s Public Education office. She has also developed and taught Egyptology courses at The University of Chicago and Loyola University Chicago.

There are 8 references cited in this article, which can be found at the bottom of the page.

This article has been fact-checked, ensuring the accuracy of any cited facts and confirming the authority of its sources.

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If you have painful sores in your mouth or throat due to an infection, chemotherapy medication, or another underlying medical condition, it can be hard to get relief. Magic mouthwash is a soothing cocktail of topical medications that can reduce your pain and help those sores heal faster. The best way to get magic mouthwash is to ask your doctor for a prescription, but we’ll give you tips on how to make a simpler version at home for quick relief.

Magic Mouthwash Lite

• Benadryl is an anticholinergic and antihistamine, which can help reduce inflammation and pain. The Maalox coats the inside of your mouth and protects the sores as they heal.
• You can get Benadryl and Maalox or Mylanta in your drug store or the pharmacy section of the grocery store.
• Unlike the prescription version of magic mouthwash, the “lite” version doesn’t have any numbing agents in it. However, it can still soothe your sores and help them heal faster.

• It won’t hurt you if you accidentally swallow a little bit, but the Benadryl might make you drowsy. [3] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source
• You can also dab the mouthwash directly on any sore areas with a cotton swab.
• You might need to use the magic mouthwash for about a week to start feeling the full benefits.

Avoid eating or drinking for about 30 minutes after you use it. If you eat or drink too soon, you’ll wash away the protective coating and it won’t be as effective. Let the mouthwash sit in your mouth for at least half an hour first. [4] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source

• Use this rinse every 4-6 hours or as often as you need to soothe your mouth pain.

Prescription Magic Mouthwash

• Magic mouthwash formulas vary, but most of them contain a mixture of antibiotics, antifungals, steroids or antihistamines, and some sort of numbing agent (such as lidocaine). [6] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source
• Your pharmacist might make a magic mouthwash using a premade kit, or mix up a specialized one based on your doctor’s orders.

• For instance, your doctor might recommend mixing 1 to 3 parts Maalox with 1 part viscous lidocaine.
• One advantage of mixing your own mouthwash is that it is usually less expensive than the pre-mixed prescription version.

• Ask your doctor if you should spit or swallow the mouthwash. In some cases, they may advise you to swallow the mouthwash to treat ulcers in your throat or esophagus. [8] X Research source
• Your doctor will tell you how long to keep using the magic mouthwash. Typically, you’ll start to feel relief in about a week. [9] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source

• For example, you might need other treatments along with magic mouthwash if your sores are caused by oral thrush, the herpes virus, or an autoimmune disease.

Safety Precautions

• You’re more likely to notice side effects if you swallow your magic mouthwash instead of spitting it out.
• If you accidentally swallow a large amount of magic mouthwash, call your doctor or a poison control center. Keep the bottle on hand so you can tell them what ingredients are in your mouthwash.

• Your doctor will be able to determine the balance of ingredients that’s right for your needs.

• If your child has mouth sores, your doctor might recommend starting with a gentler treatment, such as a saltwater and baking soda rinse. [13] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source

Johnny Depp's portrayal of Captain Jack Sparrow, in particular, was highly praised for its unique and eccentric charm. The film's success at the box office exceeded expectations, earning over $654 million worldwide. One of the notable aspects of the Curse of the Black Pearl is its successful blend of action, adventure, humor, and supernatural elements.

Expert Q&A

Dr. Pradeep Adatrow is the only board certified Dentist, Periodontist, and Prosthodontist in the southern United States. With over 15 years of experience, Dr. Adatrow specializes in dental implants, TMJ treatments, periodontal plastic surgery, surgical and non-surgical periodontics, bone regeneration, laser treatments, and soft tissue and gum graft procedures. He received a BS in Epidemiology and Biostatistics from the University of Alabama and earned his Doctor of Dental Surgery (DDS) degree from the University of Tennessee College of Dentistry. Dr. Adatrow then completed a three-year postgraduate program in periodontics and implantology at Indiana University and went on to complete another three-year postdoctoral program in advanced prosthodontics from the University of Tennessee. He also serves as a full-time professor and the Director of Surgical Prosthodontics at the University of Tennessee. Dr. Adatrow received the Dean's Junior Faculty Award and the John Diggs Faculty Award, and he was inducted into the Deans Odontological Society. He is board certified by the American Board of Periodontology and is a Fellow of the prestigious International College of Dentistry – a feat that only 10,000 others worldwide can claim.

Aloe vera! Aloe vera possesses soothing and healing properties. Dilute aloe vera juice in an equal amount of water and use this preparation as a mouthwash. Swish it around your mouth for 30 seconds before spitting it out.

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Magic mouthwash walgreens

COMPOUNDING

Statutes, Rules, and Standards Governing Compounding

Q: Which Board rules specifically govern the preparation of compounded drug products?

A: Board Rule .2801 governs the preparation of compounded drug products. Compounding is also governed by the federal Drug Quality and Security Act and by applicable United States Pharmacopeia chapter standards, which are incorporated as a matter of federal and state law.

Q: What federal law governs the preparation of compounded drug products?

A: The Drug Quality and Security Act of 2013 (“DQSA”) broadly governs the compounding of drug products by pharmacies. The Food and Drug Administration maintains comprehensive guidance on the DQSA’s provisions, associated guidance documents, and FDA policies here: FDA Human Drug Compounding Resource Page
The basic contours of the DQSA are discussed in a two-part article published by the National Association of Boards of Pharmacy titled “The Drug Quality and Security Act: What Does It Mean for Compounding Pharmacies?” Part 1 and Part 2.

Q: Does the federal Drug Quality and Security Act prohibit a pharmacy from compounding veterinary drugs for “office use”?

A: No. The federal Drug Quality and Security Act speaks to compounding of human drug products. The FDA’s most current statement of regulatory policy governing veterinary compounding may be found here: FDA Regulation of Animal Drugs. Included in the resources at this link is FDA’s final Guidance for Industry #256, Compounding Animal Drugs from Bulk Drug Substances.

Q: My pharmacy engages in compounding. How should this be reported to the Board and what information should be provided?

A: Pharmacies that hold a permit from the North Carolina Board of Pharmacy and that engage in any type of compounding are required to notify the Board. Such pharmacies must report (both on an initial permit application and as part of each annual renewal): (1) whether they compound; (2) whether the pharmacy engages in non-sterile compounding; and (3) whether the pharmacy engages in sterile compounding.

Q: Do United States Pharmacopeia (“USP”) chapter standards apply to drug product compounding as a matter of law?

A: Yes. Both the federal DQSA and North Carolina Board of Pharmacy rule incorporate applicable USP chapter standards governing the preparation of non-sterile and sterile compounded drug products.

USP chapter governs non-sterile compounded drug product preparation: USP General Chapter

USP chapter governs compounded sterile drug product preparation: USP General Chapter

USP chapter governs the handling of hazardous substances. It is incorporated into revised USP chapters and that became effective November 1, 2023, and therefore applies to compounding activities involving hazardous drug products after that date: USP General Chapter

USP chapter governs compounding activities involving radiopharmaceuticals. It is incorporated into revised USP chapters and that became effective November 1, 2023, and therefore applies to compounding activities involving radiopharmaceuticals after that date: USP General Chapter

Q: What are the USP certification requirements for sterile compounding facilities?

A: All certification testing and documentation must be compliant with USP Chapter . See Board Rule .2801. The Pharmacy Manager and/or Designated Compounding Pharmacist should review certification and environmental sampling reports to ensure that appropriate tests are performed and are in compliance with USP Chapter and that the results are compliant with the action levels set forth in USP Chapter . This guidance discusses certification tests and required documentation for a sterile compounding facility and sterile compounding equipment. It also provides guidance on environmental sampling and documentation requirements.

Q: What are the compounding record and master formulation record requirements for sterile compounded products?

A: USP Chapter requires that a compounding record be created and maintained. Board rules have always required a compounding record and did so well before implementation and enforcement of USP standards for compounding: Guidance to Compounding Record and Master Formulation Record Requirements

Q: Does USP chapter apply to non-compounding activities involving hazardous substances?

A: Yes, but in North Carolina, USP chapter is not enforceable under Board rule for non-compounding activities. The Board views compliance as a best practice for pharmacies who are doing non-compounding activities with hazardous medications. As pharmacists know, USP Chapter standards are designed to protect pharmacists, pharmacy staff, patients, and the public from the harmful effects of exposure to hazardous medications.

As USP Chapter standards for non-compounding activities become commonly followed, North Carolina law is likely to reflect that doing so is considered standard of practice. In that case, failure to comply may be evidence of negligence. Therefore, you are encouraged to evaluate (and to continue to re-evaluate) to what extent compliance reflects the appropriate standard of care. Board staff will continue to make observations during inspections to help identify potential risk for handling Hazardous Medications and will provide education on how to comply with USP Chapter standards to minimize risk to pharmacy staff, patients, and the public. These observations regarding USP Chapter compliance in non-compounding activities involving Hazardous Medications will not, by themselves, serve as a basis for disciplinary action by the Board: Board Statement on USP Chapter and Non-Compounding Activities

Board Staff have created helpful educational information that addresses identification of Hazardous Drugs, instructions on conducting an Assessment of Risk, and templates for non-compounding pharmacies to develop Standard Operating Procedures (SOPs) addressed in USP. This informational material is for pharmacies that DO NOT compound with hazardous medications: Guidance on USP Assessment of Risk and Other Educational Information.

Specific Compounded Products

Q: When is compounding of semaglutide permissible?

A: On April 28, 2023, FDA officials clarified semaglutide’s shortage status. This statement has been updated to reflect that FDA clarification. In response to several inquiries, Board staff have assembled a statement concerning if, when, and how semaglutide may be compounded: http://www.ncbop.org/PDF/SemaglutideCompounding.pdf.

Q: May I compound a copy of a commercially available product?

A: In general, no. The federal Food Drug & Cosmetic Act prohibits pharmacies from compounding “drug products that are essentially copies of a commercially available drug product.” FD&C Act § 503A(b)(1)(D)
FDA has issued enforcement guidance on how the “essential copy” restriction is interpreted and applied: Compounded Drug Products That Are Essentially Copies of a Commercially Available Drug Product Under Section 503A of the Federal Food, Drug, and Cosmetic Act

FDA does not consider a drug to be “commercially available” if it appears in FDA's Shortage Database. On April 27, 2023, FDA officials clarified that a drug is considered in shortage by the FDA if it is listed in the database and its “status” is described as “currently in shortage.”

When compounding any drug product, the substances used to compound must: (1) comply with the standards of an applicable United States Pharmacopeia (USP) or National Formulary (NF) monograph, if a monograph exists, and the USP chapter on pharmacy compounding; (2) if such a monograph does not exist, then the substances used must be components of drugs approved by the Secretary [of HHS]; or (3) if such a monograph does not exist and the drug substance is not a component of a drug approved by the Secretary [of HHS], appear on a list developed by the Secretary through regulation. FD&C Act § 503A(b)(1)(A)(i)

The pharmacy must ensure that the API used in compounding is a pharmaceutical grade product, accompanied by a valid certificate of analysis, and is sourced from an establishment registered with FDA under Section 510 of the FD&C Act. FD&C Act § 503A(b)(1)(A)(ii) – (iii)

Q: Is adding flavoring to a conventionally manufactured product considered compounding?

A: USP considers adding flavoring to a conventionally manufactured product to fall within the scope of compounding, because there are known instances when flavoring components have destabilized a product. If a pharmacy adds flavoring to a manufactured product it must take into account the manufacturer’s Beyond Use Date (BUD) and the effect on stability caused by adding flavoring. If a flavoring component is added to a manufactured product that does not contain a preservative (e.g., reconstitution of amoxicillin oral suspension) the BUD is 14 days refrigerated or shorter if indicated in the manufacturer’s labeling. If a flavoring component is added to a manufactured product that contains a preservative (e.g., pyridostigmine oral solution), then the BUD is 35 days in controlled room temperature or refrigerated or shorter if indicated in the manufacturer’s labeling. When adding flavoring the compounding record must include the flavor manufacturer or product, lot number, and expiration date. All of this information about the flavoring must be documented in the patient record notes for the prescription.

Q: Is it permissible to compound domperidone?

A: Domperidone compounding is permissible only as part of an investigational new drug application (IND). Domperidone is not a drug approved for human use in the United States. Accordingly, any domperidone product dispensed in the United States outside of an IND is unapproved, adulterated, and misbranded under both federal and North Carolina law. Notwithstanding misleading Internet information to the contrary, it is not legal in the United States to acquire, compound, dispense, or administer domperidone outside of an IND. The FDA has long provided clear guidance on this point, which may be found here: How to Request Domperidone for Expanded Access Use

As FDA’s information further states, “FDA has determined that domperidone should not be compounded or used to enhance breast milk production in lactating women.” Domperidone may be useful for “some patients with severe gastrointestinal disorders . . . that are refractory to standard therapy.” A physician who would like to prescribe domperidone for this indication may contact FDA to open an Investigational New Drug Application (IND). An FDA-authorized IND would “allow the importation, interstate shipment, and administration of the drug even though it is not approved for sale in the U.S.”

Q: What is the formulation for UNC Health Care’s Mucositis Mixture, also known as “Sleepy Butter”?

A: UNC Health Care’s Mucositis Mixture is a part of the system’s formulary. The approved recipe by the Pharmacy and Therapeutics Committee is:

Diphenhydramine liquid 2.5 mg/mL
Maalox suspension (or formulary equivalent)
Lidocaine, viscous 2%

Admix equal volumes of the three ingredients. UNC usually dispenses 300 mL total volume.

Oral Formulation. USP requires that water-containing oral formulations be assigned a BUD that is no longer than 14 days under refrigerated storage conditions. The directions for an oral formulation of Mucositis Mixture would be “swish and swallow” or similar.

Mucosal Liquid Formulation. USP requires that water-containing topical, dermal, and mucosal liquid and semisolid formulations be assigned a beyond used date (BUD) that is no longer than 30 days under room temperature storage. The directions for a mucosal liquid formulation of Mucositis Mixture would be “swish and spit” or similar.

If a pharmacy compounds one batch of Mucositis Mixture to fulfil all Mucositis Mixture prescriptions – whether the directions are “swish and spit” mucosal formulation or “swish and swallow” oral formulations – the assigned beyond used date (BUD) must be the stricter one: no longer than 14 days under refrigerated storage.

USP allows for a longer BUD for Mucositis Mixture Mouthwash if the pharmacy has independent stability data justifying the extended BUD.

Q: How do I prepare “Duke’s Magic Mouthwash”?

A: Pharmacists occasionally receive a prescription to compound “Duke’s Magic Mouthwash” that does not contain further information about the compound’s composition. The default formula for Duke’s Magic Mouthwash is:

1. Nystatin Suspension, 100,000 u/ml, 30 mL. or Nystatin Powder 3 Million Units
2. Hydrocortisone 60 mg.
3. Diphenhydramine HCL Syrup
q.s. ad. 240 ml.

The appropriate USP BUD for Magic Mouthwash depends on whether it is compounded and dispensed as an oral formulation or as a mucosal formulation.

Oral Formulation. USP requires that water-containing oral formulations be assigned a beyond used date (BUD) that is no longer than 14 days under refrigerated storage conditions. The directions for an oral formulation of Magic Mouthwash would be “swish and swallow” or similar.

Mucosal Liquid Formulation. USP requires that water-containing topical, dermal, and mucosal liquid and semisolid formulations be assigned a beyond used date BUD that is no longer than 30 days under room temperature storage. The directions for a mucosal liquid formulation of Magic Mouthwash would be “swish and spit” or similar.

If a pharmacy compounds one batch of Magic Mouthwash to fulfil all Magic Mouthwash prescriptions – whether the directions are “swish and spit” mucosal formulation or “swish and swallow” oral formulations – the assigned beyond used date (BUD) must be the stricter one: no longer than 14 days under refrigerated storage.

USP allows for a longer BUD for Magic Mouthwash if the pharmacy has independent stability data justifying the extended BUD.

Q: Is it ok to use tap water to reconstitute medications?

A: No, USP states that Purified Water shall be used for compounding nonsterile drug preparations when formulations indicate the inclusion of water. This is also required when reconstituting medications such as antibiotics. Purified Water is different than Sterile water for irrigation. Sterile water for irrigation is not considered potable water and is not intended for oral administration.

Walgreens Drive-Thru Isn't Just for Prescription Pick-up Anymore, as Company Expands Product Pick-up Offering at Its Drive-Thrus Nationwide

DEERFIELD, Ill., March 27, 2020 - As more and more people across the country continue to look for safe and convenient options to pick up daily essentials amidst the COVID-19 pandemic, Walgreens is now offering select products at its more than 7,300 pharmacy drive-thrus nationwide. The offering provides greater convenience while also helping to promote social distancing, and is another way Walgreens is helping to support patients and customers during this time.

More than 60 front-end products are currently available for purchase at drive-thru, including household essentials chosen specifically to support the needs of customers and communities during the pandemic. These additional products include cleaning supplies and sanitizers, select over the counter products such as cough/cold, pain/fever and immunity support, select grocery items, infant formula/adult nutrition, medical supplies, first aid and paper goods.

Customers may confirm product availability at the pharmacy drive-thru window. Availability and quantity restrictions apply.

“We are working around the clock to support our customers and patients, who are relying on us more now than ever before,” said Lisa Badgley, senior vice president of pharmacy and retail operations at Walgreens. “We’re continuing to quickly introduce new and different ways to meet customers’ needs for greater convenience during the COVID-19 pandemic, while also promoting social distancing as one of the most important preventive measures we can take. We also ask that customers be patient as we work to provide this new and expanded service, as there may be wait times given current demand.”

When there are no lines at the drive-thru, Walgreens pharmacy technicians are prepared to provide customers these items on the spot. In the event there are multiple vehicles in line waiting for assistance, customers may be asked to drive back around and will be provided a wait time to return to pick up their items.

About Walgreens

Walgreens (walgreens.com), one of the nation's largest drugstore chains, is included in the Retail Pharmacy USA Division of Walgreens Boots Alliance, Inc. (Nasdaq: WBA), a global leader in retail and wholesale pharmacy. Walgreens is proud to be a neighborhood health, beauty and retail destination supporting communities across the country, and was named to FORTUNE* magazine’s 2019 Companies that Change the World list. Approximately 8 million customers interact with Walgreens in stores and online each day. As of August 31, 2019, Walgreens operates 9,277 drugstores with a presence in all 50 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands, along with its omnichannel business, Walgreens.com. Walgreens also provides specialty pharmacy and mail services and offers in-store clinics and other health care services throughout the United States, most of which are operated by our health care strategic partners.

*© 2019, Fortune Media IP Limited. Used under license.

Emily Hartwig-Mekstan
Walgreens Media Relations
[email protected]

The cursed Aztec gold and the undead pirates add a haunting and mysterious atmosphere, elevating the overall experience for the audience. The film's success led to the creation of a highly lucrative franchise, with four more sequels released in the following years. The Curse of the Black Pearl set the stage for the series, establishing the beloved characters, intricate storylines, and exciting world of pirates. Overall, the Curse of the Black Pearl's release in theaters marked the beginning of a beloved and enduring franchise. Its strong performances, captivating story, and impressive visuals continue to make it a fan favorite years later..

Reviews for "Rediscover the Iconic Characters of The Curse of the Black Pearl in Theaters"

1. Sarah - 2 out of 5 stars

I was really disappointed with "Curse of the Black Pearl" when I saw it in theaters. The storyline was convoluted and confusing, with too many characters and subplots to keep track of. The action sequences were also poorly executed and relied too heavily on CGI effects, which took away from the overall enjoyment of the film. Additionally, I found the dialogue to be cheesy and forced at times, and it felt like the actors were trying too hard to be funny. Overall, I just didn't find the movie engaging or entertaining, and I wouldn't recommend it to others.

2. Michael - 2 out of 5 stars

"Curse of the Black Pearl" was a disappointment for me. While the concept of cursed pirates and treasure hunting seemed intriguing, the execution fell flat. The pacing of the film was off, with slow and drawn-out scenes followed by abrupt and rushed action sequences. The characters lacked depth and development, and it was hard to genuinely care about their fates. Additionally, the film relied too heavily on cheap humor and overused tropes, making it feel cliché and unoriginal. Overall, I was left unimpressed and unsatisfied by this supposed adventure film.

Celebrate the Legacy of The Curse of the Black Pearl with a Theatrical Release